Developing cancer therapies with the potential to prolong and improve the lives of cancer patients

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Modulating sphingolipid metabolism to potentially treat cancer and associated neuropathic pain

Well-tolerated biologic
BXQ-350 is a novel biologic that is an analog of a natural human protein and activates sphingolipids for a targeted, low-toxicity cancer treatment with an established safety profile
Unique mechanism for potential cancer treatment
By decreasing cancer-proliferating Sphingosine-1-Phosphate (S1P), and increasing anti-cancer ceramide, BXQ-350 creates an environment where cancer cells enter programmed cell death
Neuroprotective properties
Because it modulates sphingolipids that play a critical role in both cancer and pain, data suggest BXQ-350 could potentially prevent or even reverse chemotherapy-induced peripheral neuropathy (CIPN)

Addressing an unmet need

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3rd most common
CRC (Colorectal Cancer) is the 3rd most common cancer globally

153k
new CRC diagnoses and approx. 50,000 deaths in the U.S. each year*

15%
5 year Overall Survival for metastatic CRC

4 in 10
Chemotherapy Linked to Chronic Painful Neuropathy for 4 in Every 10 Patients
“BXQ-350’s mechanism of action lends itself to potential benefit in metastatic colorectal patients and peripheral neuropathy. Severe neuropathy is a major reason that patients need dose reductions or discontinuation of chemotherapy for colorectal cancer, and BXQ-350 has been shown to possess potential anti-neuropathy properties. I am excited by the potential of BXQ-350 to reduce or even potentially reverse neuropathic pain in these patients.”
Dr. Reema A. Patel, MD
Associate Professor of Medicine at the Markey Cancer Center of the University of Kentucky

Where new also means different

Bexion Pharmaceuticals, a clinical-stage biopharmaceutical company, is advancing a new class of biologic therapy aimed at treating solid tumors and chemotherapy-induced peripheral neuropathy (CIPN), with the potential to expand its portfolio into additional cancer types and broader neuropathic pain treatments. Bexion has generated promising Phase 1data across various solid tumor types, including colorectal cancer.   The Company has completed enrollment in the open-label portion of its Phase 1b/2 trial, which evaluates BXQ-350 in combination with the standard of care for newly diagnosed patients with metastatic colorectal cancer (mCRC). Additionally, Bexion has completed proof-of-concept study for treating CIPN.

Bexion Pharmaceuticals is commited to innovating and developing unique patient centered therapeutics. With a multidisciplinary team of experts, Bexion is advancing a pipeline directed at treating solid tumors and chemotherapy-induced peripheral neuropathy (CIPN). 

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Resources

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